贝伐珠单抗首次使用后出现肠梗阻1例

A Case of Intestinal Obstruction after the First Use of Bevacizumab

目的探讨贝伐珠单抗相关肠梗阻的特点,以期为贝伐珠单抗的临床应用提供参考。方法分析一例首次使用贝伐珠单抗后出现小肠梗阻的直肠癌患者病例,复习贝伐珠单抗相关肠梗阻的文献。结果总结贝伐珠单抗致肠梗阻的发生特点,包括发生率、梗阻部位等。结论尽管贝伐珠单抗致肠梗阻的发生率低,但可能产生严重后果,且其发生特点尚有较多未明确,临床使用仍需重点监护。

Objective To investigate the features of bevacizumab-related intestinal obstruction and provide reference for clinical use of bevacizumab.Methods Clinical pharmacist analyzed a case of intestinal obstruction after the first use of bevacizumab for a patient with rectal cancer.Relevant literatures were also reviewed here.Results The features were summarized of bevacizumab-associated intestinal obstruction including the incidence and the location.Conclusion Bevacizumab-associated intestinal obstruction might cause severe adverse outcome in spite of its low incidence.Since its features are still unclear,it is important to emphasize the monitoring during bevacizumab treatment for rectal cancer patients.