吡啶并[3′,2′:4,5]噻吩并[3,2-d]嘧啶类衍生物的研究进展

Research Progress on Pyrido[3',2':4,5]thieno[3,2-d]Pyrimidine Derivatives

吡啶并[3′,2′:4,5]噻吩并[3,2-d]嘧啶类衍生物具有独特的化学结构和多元杂环原子,类似于天然产物稠杂环生物碱具有广泛的生物活性和较低生物毒性,得到科研人员的关注。本文通过嘧啶环上2、3、4位和其他类型取代衍生物进行分类,改变不同位置的取代基团,具有多种生物活性,尤其在抗肿瘤方面能够显著提高抑制肿瘤细胞生长,概述了吡啶并[3′,2′:4,5]噻吩并[3,2-d]嘧啶类衍生物的合成方法和生物活性的研究,展望了稠杂环药物分子的设计方向和发展前景。

Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine derivatives have a unique chemical structure and multiple heterocyclic atoms,similar to natural products,fused heterocyclic alkaloids,have a wide range of biological activities and lower biological toxicity,and have attracted the attention of scientific researchers.The derivatives were classified at positions 2,3,4 and other types of substitutions on the pyrimidine ring.Changing the substitution groups at different positions had a variety of biological activities,especially in terms of anti-tumor,which can significantly improve the activity of inhibiting tumor cell growth.A brief review of the research progress in the synthetic methods and biological activity was presented.And the design direction and development prospects of fused heterocyclic drug molecules were prospected.