脂肪组织炎性反应的研究进展

Research progress of inflammatory response of adipose tissue

本文探讨了与脂肪组织炎性反应相关的脂质介质,促炎介质:环氧合酶衍生的二十烷类化合物(如前列腺素);促炎性反应消退介质:由ω-6-多不饱和脂肪酸产生的脂氧素,以及由ω-3-多不饱和脂肪酸产生的消退素等。炎性反应的治疗不应局限于急性级联拮抗剂或抑制剂的使用,而应扩大到考虑炎性反应消退阶段诱导剂或激动剂的巨大治疗潜力。

This review reported lipid mediators associated with inflammatory responses in adipose tissue,pro-inflammatory mediators:eicosane compounds derived from cyclooxy-genase(e.g.prostaglandins);Pro-resolving mediators:lipoxins produced by omega-6 polyunsaturated fatty acids,and resolvins produced by omega-3 polyunsaturated fatty acids.The treatment of inflammatory responses should not be limited to the use of acute cascade antagonists or inhibitors,but should be expanded to take into account the great therapeutic potential of inducers or agonists in the inflammatory resolution phase.