强迫症患者前瞻记忆缺损性质及内表型

Study on prospective memory deficits of obsessive-compulsive disorder patients in the endophenotype framework

目的考察强迫症患者前瞻记忆功能缺损情况以及强迫症患者未患病一级亲属的前瞻记忆功能,验证前瞻记忆作为强迫症内表型的潜在可能。方法选择年龄、受教育程度、性别、智商、婚姻状况相匹配的健康对照组、强迫症患者和强迫症患者一级亲属各25例,进行多试次设计的标准化前瞻记忆任务,将被试的正确反应率作为前瞻记忆功能的指标。结果强迫症患者组在基于事件的前瞻记忆和基于时间的前瞻记忆任务中正确率均低于健康对照组,差异均有统计学意义[(0.74±0.24)vs.(0.88±0.13),d=-0.140,P=0.044;(0.77±0.21)vs.(0.93±0.10),d=-0.164,P=0.011],强迫症患者一级亲属组在基于事件的前瞻记忆任务中正确率低于健康对照组,差异有统计学意义[(0.73±0.20)vs.(0.88±0.13),d=-0.144,P=0.036]。结论强迫症患者前瞻记忆缺损较广泛,且前瞻记忆可能是强迫症的一种内表型。

Objective To study the prospective memory deficits of obsessive-compulsive disorder patients and unaffected first-degree relatives of patients,so as to validate the possibility of prospective memory as an endophenotype of obsessive-compulsive disorder.Methods Healthy controls,obsessive-compulsive disorder patients and unaffected first-degree relatives of patients,each with 25 cases,matched for age,education,gender,IQ and marriage status were enrolled.The standardized prospective memory paradigm with a multi-trial design was conducted,and the accuracy was used as an indicator of prospective memory function.Results The accuracy of event-and time-based prospective memory tasks of obsessive-compulsive disorder patients was lower than that of healthy controls,with statistical differences[(0.74±0.24)vs.(0.88±0.13),d=-0.140,P=0.044;(0.77±0.21)vs.(0.93±0.10),d=-0.164,P=0.011].The accuracy of event-based prospective memory task of unaffected first-degree relatives was also lower than that of healthy controls,with statistical difference[(0.73±0.20)vs.(0.88±0.13),d=-0.144,P=0.036].Conclusion Obsessive-compulsive disorder patients has extensive prospective memory deficits,indicating that prospective memory may be an endophenotype of obsessive-compulsive disorder.