肺炎支原体发病机制及诊治研究进展

Research Progress ofPathogenesis,Diagnosis and Treatment of Mycoplasma Pneumoniae

肺炎支原体是一种介于病毒与细菌之间的非活性生长微生物,是造成肺炎、支气管炎的重要病原体,还可导致皮肤及神经、血液、泌尿等多系统病变。支原体肺炎多发于青少年,其发病率呈上升趋势,其中难治性支原体肺炎发病率也越来越多,其患者多表现为对大环内酯类抗生素不敏感,导致治疗困难,病程长且易反复,长期无法治愈可导致部分脏器受损,危及患者生命安全。支原体肺炎发病机制较为复杂,本文就肺炎支原体发病机制、诊断、治疗的研究进行综述。

As a free-livingmicroorganismintermediate between viruses and bacteria,mycoplasma pneumoniae is an important pathogen that causes pneumonia and bronchitis,as well as the lesionin skin,nerve,blood,urinary and other systems.Mycoplasma pneumoniamostly occurs in adolescents,anditsincidence,including that ofrefractory mycoplasma pneumonia is on the rise.Patients with refractory mycoplasma pneumoniaare insensitive to macrolide antibiotics,adding to the difficulty of treatment.Also,the long course and relapseof the disease may lead to the damage of organs,which endangers the lives of patients.This paper thus reviews the complicated pathogenesis,diagnosis and treatment of mycoplasma pneumonia.