衣原体致病机制研究进展

Research progress on the pathogenesis of Chlamydia

衣原体是一类具有独特两相发育周期的专性胞内寄生菌,可引起人类多种疾病。衣原体致病主要依赖菌体脂多糖、膜蛋白、质粒编码蛋白、分泌的效应因子等,其或介导衣原体黏附和入侵宿主、引起炎症和病理损伤,或调控宿主细胞功能以利衣原体胞内生长,或抑制宿主免疫细胞以便衣原体逃逸免疫杀伤。这些发现在分子水平上阐述了衣原体的致病机制,为更好地诊断、治疗、预防衣原体感染提供新的理论基础。

Chlamydia is an obligate intracellular parasite with a unique biphasic development cycle that can cause various diseases in humans.The pathogenicity of Chlamydia depends mainly on lipopolysaccharides,membrane proteins,plasmid-encoded proteins,and secreted effectors,which may mediate adhesion and invasion of the host to cause inflammation and pathological damage or regulate the functions of host cells to facilitate intracellular growth,or suppress host immune cells to evade the immune system.These findings explain the pathogenic mechanisms of Chlamydia at the molecular level and provide a new theoretical basis for better diagnosis,treatment,and prevention of Chlamydia infection.