口腔颌面部肉瘤30例临床分析

A clinical study of 30 cases of oral and maxillofacial sarcoma

目的总结口腔颌面部肉瘤的病理分型、临床表现、治疗及预后特点。方法收集2008年1月至2019年1月就诊于首都医科大学附属北京口腔医院的30例口腔颌面部肉瘤患者的临床资料,包括患者的性别、发病年龄、病理分型、肿瘤大小、原发部位、复发或转移、治疗及预后,并对患者的资料进行回顾分析。结果30例患者中男性17例,女性13例,男女比例1.3:1;平均发病年龄38.1岁(11~71岁)。骨组织来源的16例,软组织及其他来源14例。30例患者均接受外科手术为主的综合治疗。平均随访59.6月(8~136月),末次随访时,6例患者因局部复发死亡,1例远处转移死亡,1例淋巴转移死亡,1例意外死亡,5例患者局部复发再治疗后生存,其余患者未发生复发、转移。结论本研究中口腔颌面部肉瘤病例生存率总体优于既往文献报道。局部复发为死亡的主要原因,根治性的手术切除是提高口腔颌面部肉瘤患者预后的最重要因素。

Objective To summarize the histopathological subtype,clinical presentation,treatment modalities and prognosis of oral and maxillofacial sarcoma.Methods A total of 30 cases of oral and maxillofacial sarcoma were included.The clinical data inclding gender,age,histopathological subtype,the primary site,recurrence or metastasis,treatment and prognosis were reviewed.Results Among the 30 patients,17 were male and 13 were female.The mean age of onset was 38.1 years(11-71 years).In all the histopathological subtypes,16 were from hard tissue,and 14 cases were from soft tissue and other sources.All patients received surgery oriented comprehensive therapy.The 30 cases were followed up for an average period of 59.6 months(8-136 months).Six cases died of local recurrence,1 case died of distant metastases,1 case died of lymph node metastases,1 case died of accident,5 cases of local recurrence received secondary treatment and survived.There was no recurrence or metastasis in other cases.Conclusions In this study,the overall survival of oral and maxillofacial sarcoma was better than that reported in previous literatures.Local recurrence was the common and main cause of death.The radical surgical resection is the most important factor on improving the prognosis of patients.