摘要
Malaria transmission can be affected by multiple or even hidden factors,making it difficult to timely and accurately predict the impact of elimination and eradication programs that have been undertaken and the potential resurgence and spread that may continue to emerge.One approach at the moment is to develop and deploy surveillance systems in an attempt to identify them as timely as possible and thus to enable policy makers to modify and implement strategies for further preventing the transmission.Most of the surveillance data will be of temporal and spatial nature.From an interdisciplinary point of view,it would be interesting to ask the following important as well as challenging question:Based on the available surveillance data in temporal and spatial forms,how can we build a more effective surveillance mechanism for monitoring and early detecting the relative prevalence and transmission patterns of malaria?What we can note from the existing clustering-based surveillance software systems is that they do not infer the underlying transmission networks of malaria.However,such networks can be quite informative and insightful as they characterize how malaria transmits from one place to another.They can also in turn allow public health policy makers and researchers to uncover the hidden and interacting factors such as environment,genetics and ecology and to discover/predict malaria transmission patterns/trends.The network perspective further extends the present approaches to modelling malaria transmission based on a set of chosen factors.In this article,we survey the related work on transmission network inference,discuss how such an approach can be utilized in developing an effective computational means for inferring malaria transmission networks based on partial surveillance data,and what methodological steps and issues may be involved in its formulation and validation.
基金
The authors would like to acknowledge the funding support of Hong Kong Research Grants Council(RGC)for the work being presented in this article(HKBU211212)
Bo Yang would also like to acknowledge the support of Chinese Program for New Century Excellent Talents in University(NCET-11-0204).
