摘要
Background:It is estimated that there are about 74,000 primary multidrug-resistant tuberculosis(MDR-TB)patients per year according to the prevalence of MDR-TB of 5.7%among new TB patients in China.Thus,the risks of primary transmission of MDR-TB require further attention.This study aimed to identify the factors associated with primary transmission of MDR-TB in Henan province,where the number of new TB patients is ranked second highest in China.Methods:A 1:1 matched case–control study was conducted in Henan,China.Cases were primary MDR-TB patients who were individually matched with a healthy control without TB from the same neighborhood.The study was conducted from July 2013 to June 2014.Both case and control were matched by age(±5 years)and sex.Conditional logistic regression was used to compute adjusted odds ratios(AORs)with corresponding 95%confidence intervals(CIs)for risk factors associated with primary MDR-TB.Results:For the study,146 pairs of participants were recruited.The final multivariable logistic regression model disclosed that after adjusting for age and sex,primary MDR-TB cases were more likely to be single(AOR,5.4;95%CI,1.4–20.7),earn an annual income of≤12,000 yuan(RMB)(AOR,9.9;95%CI,2.0–48.1),experience more life pressure/stress(AOR,10.8;95%CI,2.8–41.5),not be medically insured(AOR,50.1;95%CI,8.2–306.8),and suffer from diabetes,cardiovascular disease or other respiratory diseases,or cancer(AOR,57.1;95%CI,8.6–424.2).Conclusions:In order to control primary transmission of MDR-TB in China,we recommend that improving the social support,living standards and medical security of the lower social class become a priority.
