经阴道彩色多普勒超声检查卵巢癌患者血流指标与肿瘤恶性度和血管新生的关系

Relationship between transvaginal color Doppler ultrasound blood flow parameter and tumor malignancy and angiogenesis in patients with ovarian cancer

目的探讨经阴道彩色多普勒超声检查卵巢癌患者血流指标与肿瘤恶性度和血管新生的关系。方法选取2019年2月至2021年1月间渭南市中心医院收治的40例卵巢癌患者为研究组,选取同期42例卵巢良性肿瘤患者为对照组,两组患者均行经阴道彩色多普勒超声检查,比较两组患者彩色多普勒超声血流指标[阻力指数(RI)、动脉血管搏动指数(PI)、舒张末期流速(EDV)与平均流速(VM)]、血管新生指标[血管内皮生长因子(VEGF)、鞘氨醇激酶1(SPHK1)、鞘氨醇激酶2(SPHK2)、微血管密度(MVD)],比较研究组不同分期患者彩色多普勒超声血流指标和血管新生指标,分析研究组患者彩色多普勒超声血流指标与血管新生指标表达的相关性。结果研究组患者RI和PI指标低于对照组,EDV和VM指标高于对照组,差异均有统计学意义(均P<0.05)。研究组Ⅲ~Ⅳ期患者RI和PI指标低于Ⅰ~Ⅱ期患者,EDV与VM指标高于Ⅰ~Ⅱ期患者,差异均有统计学意义(均P<0.05)。研究组患者VEGF、SPHK1、SPHK2和MVD均高于对照组,差异均有统计学意义(均P<0.05)。研究组Ⅲ~Ⅳ期患者VEGF、SPHK1、SPHK2和MVD均高于Ⅰ~Ⅱ期患者,差异均有统计学意义(均P<0.05)。研究组患者RI和PI与VEGF、SPHK1、SPHK2和MVD水平均呈负相关,EDV和VM与VEGF、SPHK1、SPHK2和MVD水平均呈正相关性(均P<0.05)。结论经阴道彩色多普勒超声检查卵巢癌患者血流指标与肿瘤恶性度和血管新生有密切相关性,为临床评估卵巢癌病情提供了可靠参考,具有应用价值。

Objective To investigate the relationship between transvaginal color Doppler ultrasound blood flow parameters and tumor malignancy and angiogenesis in patients with ovarian cancer. Methods Forty patients with ovarian cancer admitted to Weinan Central Hospital were selected and enrolled in an experimental group from February 2019 to January 2021. Another 42 patients with benign ovarian tumors were selected and enrolled in a control group at the same hospital during the same period. Both groups were examined by transvaginal color Doppler ultrasound. ultrasound blood flow parameters including arterial resistance index( RI) and pulsatility index( PI),end diastolic velocity( EDV) and mean blood flow velocity( VM) and angiogenesis parameters including vascular endothelial growth factor( VEGF),sphingosine kinase 1( SPHK1),SPHK2 and microvascular density( MVD) were compared between the two groups. Relationship between transvaginal color Doppler ultrasound blood flow parameters and angiogenesis expression was analyzed. Results RI and PI were lower in the experimental group than in the control group and EDV and VM were higher in the experimental group than in the control group( all P<0.05). In the experimental group,RI and PI were lower in patients with stage Ⅲ to Ⅳ ovarian cancer than in patients with stage Ⅰ toⅡ cancer and EDV and VM were higher in patients with stage Ⅲ to Ⅳ ovarian cancer than in patients with stage Ⅰ to Ⅱ cancer( all P<0.05). VEGF,SPHK1,SPHK2 and MVD were higher in the experimental group than in the control group( all P<0.05). In the experimental group,VEGF,SPHK1,SPHK2 and MVD were higher in patients with stage Ⅲ to Ⅳ ovarian cancer than in patients with stage Ⅰ to Ⅱ cancer( all P<0.05). In the experimental group,RI and PI were negatively associated with VEGF,SPHK1,SPHK2 and MVD and EDV and VM were positively associated with VEGF,SPHK1,SPHK2 and MVD( all P<0.05). Conclusion Transvaginal Color Doppler ultrasound blood flow parameters were closely associated with tumor malignancy and angiogenesis in patients with ovarian cancer. It provides a reliable reference for clinical evaluation of ovarian cancer.