慢性精神分裂症患者精神症状与甲状腺激素水平相关性分析

Correlation between mental symptoms and thyroid hormone levels in patients with chronic schizophrenia

目的探讨慢性精神分裂症患者的精神症状与甲状腺激素水平的相关性。方法选取403例慢性精神分裂症患者作为研究组及100例健康受试者为对照组。分别测定研究组与对照组的TSH、FT3、FT4水平,研究组在入组时采用PANSS量表和卡加里精神分裂症抑郁量表对患者的精神症状进行评定。结果研究组与对照组的甲状腺激素水平无差异,但研究组男性的FT3水平明显高于女性(P=0.01)。在慢性精神分裂症患者中,FT3、FT4水平与精神症状无明显相关性,TSH水平与兴奋症状呈负相关(r=-0.110,P=0.027)。结论慢性精神分裂症患者的兴奋症状与TSH水平有关,可通过TSH水平预测患者兴奋症状的严重程度,而FT3、FT4水平与精神症状无关。

Objective To investigate the correlation between mental symptoms and thyroid hormone levels in patients with chronic schizophrenia.Methods Four hundred and three patients with chronic schizophrenia were selected as the study group and 100 healthy subjects as the control group.The levels of TSH,FT3 and FT4 in the study group and the control group were measured respectively.The mental symptoms of the study group were evaluated by PANSS and Calgary Depression Scale.Results There was no difference in thyroid hormone levels between patients with chronic schizophrenia and healthy subjects, but FT3 levels in men were significantly higher than those in women(P=0.01).In patients with chronic schizophrenia, the levels of FT3 and FT4 were not significantly correlated with psychiatric symptoms, but TSH level was negatively correlated with excitement symptoms(r=-0.110,P=0.027).Conclusion Excitement symptoms are related to TSH levels in patients with chronic schizophrenia.the level of TSH can be used to predict the severity of excitement symptoms, but the levels of FT3 and FT4 have nothing to do with mental symptoms.