宫颈糜烂患者宫颈分泌物中沙眼衣原体、解脲支原体感染和分泌型免疫球蛋白、干扰素-γ水平及意义

Levels of CT,Uu Infection,SIgA and IFN-γin Cervical Secretions of Patients with Cervical Erosion and their Significance

目的:探讨宫颈糜烂患者宫颈分泌物中沙眼衣原体(CT)、解脲支原体(Uu)感染和分泌型免疫球蛋白(sI-gA)、干扰素-γ(IFN-γ)水平及意义。方法:选取2018年2月—2019年3月在鹤壁市京立医院治疗的宫颈糜烂患者110例(观察组),同时选取健康志愿者60例作为对照组,检测宫颈分泌物中CT、Uu感染及sIgA、IFN-γ水平。结果:观察组宫颈分泌物中CT、Uu感染率分别为23.64%和31.82%,sIgA和IFN-γ分别为(80.64±9.97)μg/mL和(81.14±9.54)ng/L,明显高于对照组(P<0.05);观察组重度患者宫颈分泌物中CT、Uu感染率分别为35.56%和48.89%,sIgA和IFN-γ分别为(92.72±9.55)μg/mL和(89.21±9.98)ng/L,明显高于轻中度患者(P<0.05);观察组宫颈分泌物CT、Uu感染者sIgA和IFN-γ分别为(84.45±10.15)μg/mL和(85.02±9.97)ng/L,明显高于非病原感染患者(P<0.05)。结论:宫颈糜烂患者宫颈分泌物中CT、Uu感染率上升,同时sIgA、IFN-水平升高,与病情严重程度有一定关系。

Objective:To investigate the levels and significance of Chlamydia trachomatis(CT),Ureaplasma urealyticum(Uu) infection and secretory immunoglobulin(sIgA)and interferon-γ(IFN-γ)in cervical secretions of patients with cervical erosion Methods:110 patients(observation group)with cervical erosion treated in the hospital from February 2018 to March 2019 were se lected,and 60 healthy volunteers were selected as control group.The levels of CT,Uu infection,sIgA and IFN-γin cervical secre tions were detected.Results:The infection rates of CT and Uu in cervical secretions of the observation group were 23.64%and31.82%,s IgA and IFN-γin the observation group were(80.64±9.97)μg/ml and(81.14±9.54)ng/L,which were significantly higher than those in the control group(P<0.05).The infection rates of CT and Uu in cervical secretions of severe patients in the observa tion group were 35.56%and 48.89%,sIgA and IFN-γwere(92.72±9.55)μg/ml and(89.21±9.98)ng/L,which were significantly higher than those in mild and moderate patients(P<0.05).In the observation group,the levels of sIgA and IFN-γin cervical se cretion CT and Uu infected patients were(84.45±10.15)g/ml and(85.02±9.97)ng/L,which were significantly higher than those in non-pathogenic patients(P<0.05).Conclusion:The infection rate of CT and Uu in cervical secretions of patients with cervica erosion increase,while the levels of slgA and IFN-γincreased,which are related to the severity of the disease.