药物抗病毒治疗慢乙肝的最新研究进展

The Latest Research Progress of Drug Antiviral Treatment of Chronic Hepatitis B

慢性乙型肝炎(慢乙肝)传染性强、传播途径广,临床多以抗病毒治疗为主,可抑制乙肝病毒复制,减轻肝脏损害,缓解临床症状。然而常见的干扰素及核苷酸类抗病毒药物无论单一或联合使用均无法彻底清除乙肝病毒,达到彻底治愈效果。但随着对乙型肝炎病毒深入了解,多种针对不同作用靶点的药物研发取得较大进展,给慢乙肝治疗带来新的选择。本文就抗病毒药物治疗慢乙肝的最新研究进展进行以下综述。

Chronic hepatitis B(CHB)is highly contagious and has a wide range of transmission routes.It is mostly clinically based on antiviral therapy,which can inhibit the replication of HBV,reduce liver damage,and relieve clinical symptoms.However,the common interferon and nucleotide antiviral drugs cannot completely eliminate the HBV and achieve a complete cure effect,regardless of whether they are used alone or in combination.However,with the in-depth understanding of the HBV,the research and development of a variety of drugs targeting different targets has made great progress,which brings new options for the treatment of CHB.This article reviews the latest research progress of antiviral drugs in the treatment of CHB.