SEMA4D与头颈部鳞状细胞癌发生发展的生物信息学研究

Bioinformatic study of the correlation between SEMA4D and the development of head and neck squamous cell carcinoma

目的通过生物信息学分析SEMA4D与头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)发生发展的相关性。方法从癌症基因组图谱数据库(TCGA)中下载HNSCC相关临床数据。通过Wilcox秩和检验分析SEMA4D在HNSCC及其临床特征中的表达水平,采用Spearman检验计算SEMA4D表达水平与HNSCC肿瘤突变负荷(TMB)和免疫浸润细胞的相关性,采用Kaplan-Meier法计算SEMA4D对HNSCC预后的影响。结果SEMA4D在HNSCC中的表达水平显著降低,与肿瘤免疫细胞得分和免疫浸润细胞相关,高表达SEMA4D的HNSCC患者预后较好。结论生物信息学研究发现SEMA4D降低HNSCC的发病风险,提高患者的预后水平。

Objective To analyze the correlation between SEMA4D and the occurrence,development of head and neck squamous cell carcinoma(HNSCC)by bioinformatic study.Methods Clinical data related to HNSCC were downloaded from The Cancer Genome Atlas(TCGA).The expression of SEMA4D in HNSCC and its clinical characteristics was analyzed by Wilcox rank sum test.Spearman test was conducted to calculate the correlation between the expression of SEMA4D and HNSCC tumor mutation burden(TMB)as well as immune infiltrating cells.Kaplan-Meier method was used to calculate the effect of SEMA4D on the prognosis of HNSCC.Results The expression of SEMA4D in HNSCC significantly decreased,which was related to the score of tumor immune cell and immune infiltrating cells.HNSCC patients with high expression of SEMA4D had a better prognosis.Conclusion Bioinformatic analysis reveals that SEMA4D reduces the risk of HNSCC and improves the prognosis of patients.