中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与儿童IgA肾病临床及病理特点的相关性研究

Correlation study of NLR and PLR and clinico pathological characteristics of IgA nephropathy in children

目的探讨中性粒细胞/淋巴细胞比值(neutrophil/lymphocyte ratio, NLR)、血小板/淋巴细胞比值(platelet/lymphocyte ratio, PLR)与儿童IgA肾病(IgA nephropathy, IgAN)临床及病理的相关性。方法回顾性收集2017年1月1日至2019年12月1日在郑州大学第一附属医院儿科确诊的原发性IgAN患儿71例为病例组,同期健康体检儿童46例为对照组,以血常规、肾功能、24 h尿蛋白定量为指标进行比较分析。结果病例组NLR(中性粒细胞/淋巴细胞比值)高于对照组,差异有统计学意义(P<0.05),PLR(血小板/淋巴细胞比值)比较无统计学差异。相关分析示NLR、PLR与WBC、Alb、eGFR、Scr、BUN、24 hTP/体重无显著相关性。重度病理级别患儿具有更高的NLR、PLR(P<0.05);与NLR比较,PLR预测患儿高病理级别(以Lee氏Ⅲ级为界)的曲线下面积较大,特异度最高,截断值为165.71。结论 IgAN儿童较正常健康儿童具有更高的NLR,提示其体内存在慢性炎症状态;NLR、PLR在一定程度上可以反映IgAN患儿的肾脏病理损伤程度,且PLR较NLR的性能更佳。

Objective To study the correlation of NLR and PLR and clinico pathological characteristics of IgA nephropathy in children.Methods A retrospective analysis was performed for the clinical data of children with primary IgAN, as the case group and the healthy children in the same period as the control group.Results A total of 71 cases were included in the case group, and 46 cases were included in the control group. The difference of NLR were statistically significant;There was no statistical difference in PLR. Correlation analysis showed that NLR and PLR were not significantly correlated with WBC,Alb, eGFR,Scr, BUN. Compared with NLR, PLR had a larger prediction area under the ROC curve, which had the higher specificity, the cutoff value was 165.71.Conclusion Children with IgA nephropathy had higher NLR than normal healthy children, suggesting the presence of chronic inflammation in children with IgAN. NLR and PLR can reflect the degree of renal pathological injury in children with IgA nephropathy to a certain extent, and PLR has better performance than NLR.