慢性精神分裂症患者静息态脑镜像同伦连接研究

Characteristics of resting-state brain voxel-mirrored homotopic connectivity in patients with chronic schizophrenia

目的采用镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)考察慢性精神分裂症的脑表征特点。方法来自天津市安定医院的47例慢性精神分裂症患者和31例来自附近社区的健康对照纳入研究。采用西门子Skyra 3.0 T MRI扫描平台采集受试者的MRI数据,采用阳性和阴性症状量表(positive and negative symptoms scale,PANSS)评估患者症状严重程度。采用SPM12对采集的MRI数据进行处理,采用DPARSF计算两组受试样本的VMHC值,基于SPM12的独立样本t检验用于比较两组被试的VMHC值,使用Spearman秩相关分析显著脑区的VMHC和临床症状之间的相关性,将VMHC有显著差异的脑区作为感兴趣区(region of interest,ROI),使用VBM8进一步分析两组被试ROI的灰质体积。结果相比于健康对照组,慢性精神分裂症组呈现出VMHC下降[基于体素水平的拓扑FDR校正,q=0.05],主要脑区位于舌回(体素=208,T=4.98),枕中回(体素=156,T=3.75)和中央后回(体素=237,T=4.36)。VBM分析显示,与健康对照组相比,慢性精神分裂症患者双侧舌回[左侧舌回:(0.0034±0.0008),(0.0028±0.0013),t=-2.141,P=0.037;右侧舌回:(0.0025±0.0006),(0.0020±0.0011),t=2.268,P=0.028]和右侧中央后回[(0.0432±0.0051),(0.0372±0.0162),t=-2.070,P=0.045]的灰质体积增加,双侧枕中回的灰质体积无显著变化。结论慢性精神分裂症患者舌回、枕中回和中央后回双侧半球间的镜像同伦连接存在异常。

Objective To investigate the brain characteristics of chronic schizophrenia by voxel-mirrored homotopic connectivity(VMHC).Methods Forty seven patients with chronic schizophrenia from Tianjin Anding Hospital and 31 healthy controls from nearby communities were included in the study.The MRI data of the subjects were collected by Siemens Skyra 3.0 T MRI.Positive and negative symptoms scale(PANSS)was used to assess the illness severity of patients with chronic schizophrenia.SPM12 was used to process the collected MRI data.DPARSF was used to calculate the VMHC values of subjects in the two groups.The independent sample t test based on SPM12 was used to compare the VMHC values of the two groups.The significant brain regions in VMHC were regarded as regions of interest(ROI),and VBM8 was used to further analyze the gray matter volume of the ROI of the two groups.Results Compared with healthy controls,the patients with chronic schizophrenia demonstrated decreased VMHC mainly located in lingual gyrus(voxel=208,T=4.98),occipital middle occipital gyrus(voxel=156,T=3.75)and postcentral gyrus(voxel=237,T=4.36)(FDR correction,q=0.05).Compared with healthy controls,the gray matter volumes in bilateral lingual gyrus(left(0.0034±0.0008),(0.0028±0.0013),t=-2.141,P=0.037;right(0.0025±0.0006),(0.0020±0.0011),t=2.268,P=0.028)and postcentral gyrus((0.0432±0.0051),(0.0372±0.0162),t=-2.070,P=0.045)increased,but non-significant change in postcentral gyrus of the patients with chronic schizophrenia.Conclusion The abnormal VMHC mainly locate in lingual gyrus,middle occipital gyrus and postcentral gyrus in patients with chronic schizophrenia.