人乳头瘤病毒感染与阴道微生态关系的研究进展

Relationship Between Human Papillomavirus Infection and Vaginal Microecology

人乳头瘤病毒(HPV)是一种普遍存在的DNA病毒,会引起被感染者皮肤和黏膜扁平或疣状丘疹、斑块,甚至发生癌变,给人们的健康和生活带来诸多困扰。阴道微生态是阴道内微生物、阴道解剖、阴道周期性内分泌变化及阴道局部免疫系统构成的整体。目前较多研究表明,阴道微生态的改变与HPV的持续感染及尖锐湿疣、宫颈癌等疾病的预后息息相关,明确HPV感染与阴道微生态的关系可为HPV感染相关的女性生殖道疾病的治疗与预防提供帮助,提高治愈率,降低复发率。本文将近年来针对HPV感染与阴道微生态的相关研究做一综述,为今后的治疗方向奠定一定基础。

Human papillomavirus(HPV)is a ubiquitous DNA virus.It can cause flat or verrucous papules and plaques on the skin and mucous membranes,and even cancerous transformation,causing many problems to people's health and lives.The vaginal microecology is defined by microbes in the vagina,anatomy of the vagina,periodic endocrine changes of the vagina,and the local immune system of the vagina.Up to now,many studies had shown that changes in vaginal microecology are closely related to the prognosis of persistent infection,cervical cancer and other diseases.Further clarification of the relationship between HPV infection and vaginal microecology can help treat and prevent of female reproductive tract diseases related to HPV infection,improve the cure rate and reduce the relapse rate.This article summarizes the recent research on HPV infection and vaginal microecology and lays a solid foundation for future treatment.