p53基因异常在多发性骨髓瘤发病机制中的作用及其靶向治疗新进展

Advances in role of abnormal p53 gene in pathogenesis of multiple myeloma and targeted therapy

多发性骨髓瘤(MM)是一种由骨髓浆细胞恶性克隆性增殖引发的疾病。目前,MM仍无法治愈。肿瘤抑制蛋白p53功能异常影响MM的发生、发展,伴p53基因异常MM患者的预后差。然而,p53功能异常在MM发生、发展中的作用机制迄今尚未完全阐明。笔者拟就MM中的p53基因异常类型,以及针对p53基因异常的靶向治疗方案新进展进行阐述,旨在为MM患者的治疗提供新思路。

Multiple myeloma(MM)is a disease caused by malignant clonal expansion of plasma cells in bone marrow.At present,MM is still an incurable disease.Abnormal function of tumor suppressor protein p53 affects occurrence and development of MM,and MM patients with p53 gene abnormalities have a poor prognosis.However,so far mechanisms of abnormal p53 function in occurrence and development of MM have not been fully clarified.This article intends to summarize abnormal types of p53 gene in MM and new progresses in targeted therapies against p53 gene abnormality,in order to provide new thoughts for treatment of MM patients.