TRIM72蛋白与心衰患者的心肌重塑、病因以及预后关系的临床观察

Clinical Observation of the Relationship Between TRIM72 Protein and Myocardial Remodeling,Etiology and Prognosis in Patients with Heart Failure

目的观察TRIM72蛋白在心力衰竭患者血液中的表达情况(平均值以及TRIM72高表达和低表达情况),分析其与心肌重塑、心衰致病因以及与心力衰竭预后的关系。方法收集2018~2019年在巴彦淖尔市就诊的共43例临床诊断为心功能Ⅲ~Ⅳ级(纽约分级)的患者,使用酶联免疫吸附试验(ELISA)法测定心衰纠正前后两次的外周血TRIM72水平,并收集相关临床化验结果如肝肾功、血脂、离子等及心彩超结果。以有无心肌重塑分为重塑组(37例)与正常组(6例);以不同病因分为心肌疾病组(21例)、心肌负荷异常组(15例)及心律失常组(7例);以不同预后(观察期内是否出现心衰复发)分为复发组(15例)与观察组(28例)。对比所有人心衰纠正前后两次TRIM72的表达情况以及分别对比3种不同分组组间的TRIM72的表达情况是否存在差异。结果所有患者的心衰纠正前和后的TRIM72平均值未见明显差异(P>0.05);重塑组与正常组两次TRIM72的表达情况均未见明显差异(P>0.05);不同病因组两次TRIM72的表达情况均未见明显差异(P>0.05),复发组与观察组的两次TRIM72的表达情况的差异均有统计学意义(P<0.05)。结论 TRIM72蛋白可能与心衰预后相关。

Objective This topic aim to investigate the expression of TRIM72 protein(include the mean value of TRIM 72 and the high or low expression of TRIM72)in the blood of patients with heart failure,and to observe its correlation with myocardial remodeling,pathogeny and the prognosis of heart failure.Method A total of 43 patients with cardiac function gradeⅢ-IV(NYHA)who were treated in Bayannur City from 2018 to 2019 were collected,using the enzyme associated immunoadsorption test(elisa)to determine the levels of the the blood TRIM72 in the two times before and after the correction of heart failure,and collected the clinical analysis data such as hepatic and renal function,serum lipid,ions and also the echocardiography.According to the presence or absence of myocardial remodeling,patients were divided into remodeling group(37 cases)and normal group(6 cases).According to different etiology,patients were divided into myocardial disease group(21 cases),abnormal myocardial load group(15 cases)and arrhythmia group(7 cases).According to the prognosis(recurrence of heart failure during the observation period),patients were divided into recurrence group(15 cases)and observation group(28 cases).The expression of TRIM72 before and after the correction of heart failure was compared in all patients,and also compared the TRIM72 levels in different groups under different factors.Results There was no significant difference in two of the expression of TRIM72 before and after heart failure correction in all patients(P>0.05).There was no significant difference in the expression of TRIM72 between the remodeling group the normal group(P>0.05).There were no significant differences in the expression of TRIM72 between the three etiological groups(P>0.05).There were statistically significant differences in TRIM72 levels between the recurrent group and the observation group(P<0.05).Conclusions TRIM72 may be associated with the prognosis of heart failure.