COX-2基因rs20417位点与慢性阻塞性肺疾病相关性的meta分析

Relationship Between rs20417 Locus of COX-2 and COPD:a Meta-analysis

目的分析环氧合酶-2基因rs20417位点与慢性阻塞性肺疾病(简称慢阻肺)的关联性。方法检索维普、中国知网、万方医学、中国生物医学文献数据库、PubMed、EMbase、Cochrane图书馆等,检索时间从数据库成立到至2020年12月。依据文献纳入及排除标准对所有文章进行筛选,然后提取数据及质量评估,应用egger检验评价文章发表偏移情况,采用Stata 14.0对数据进行分析。结果共纳入6篇文献,结果显示,在等位基因模型(OR=1.46,95%CI 1.21~1.76,P=0.000)、显性模型(OR=1.55,95%CI 1.25~1.92,P=0.000)、共显性模型(OR=1.52,95%CI1.22~1.90,P=0.000)下COX-2基因rs20417位点与慢阻肺患病风险有关,而相加模型(OR=1.50,95%CI 0.81~2.76,P=0.193)、隐性模型(OR=0.62,95%CI 0.35~1.12,P=0.113)下COX-2基因rs20417位点与慢阻肺患病风险无关。结论人群环氧合酶-2基因rs20417位点多态性与慢阻肺发病率有关,但是对于C基因型频数低的部分中国人群及日本人等可能无关。

Objective To systematically analyze the correlation between cyclooxygenase-2 gene rs20417 locus and chronic obstructive pulmonary disease.Methods Wanfang database,CNKI database,PubMed,Chinese biomedical literature database,Cochrane library and EMbase database were searched by computer from the establishment of database to December 2020.Two researchers completed the literature reading independently.Literature screening,data extraction and quality evaluation were performed according to the inclusion and exclusion criteria.The egger test was used to evaluate the publication bias of the included literature.Stata 14.0 was used for meta-analysis.Results Six articles were included.Meta-analysis showed that the rs20417 locus of COX-2 gene was associated with the risk of COPD in allele model(OR=1.46,95%CI 1.21~1.76,P=0.000),dominant model(OR=1.55,95%CI 1.25~1.92,P=0.000)and codominant model(OR=1.52,95%CI 1.22~1.90,P=0.000).But the additive model(OR=1.50,95%CI 0.81~2.76,P=0.193)and the recessive model(OR=0.62,95%CI 0.35~1.12,P=0.113)were not associated with the risk of COPD.Conclusion The rs20417 polymorphism of COX-2 gene is associated with the incidence of COPD,but it may not be related to some Chinese and Japanese with low frequency of C genotype.