脂溢性皮炎样皮肌炎:一种特殊类型的皮肌炎

Seborrheic dermatitis-distributed dermatomyositis:a special type of dermatomyositis

介绍一种特殊类型的皮肌炎——脂溢性皮炎样皮肌炎,其特点为患者有面部脂溢性皮炎样皮疹,常伴有Gottron丘疹、反向Gottron丘疹、技工手和皮肤溃疡,很少累及肌肉。抗黑素瘤分化相关基因5抗体阳性的脂溢性皮炎样皮肌炎患者更易出现肺间质病变/急进性肺间质病变。通过皮疹联合抗体检测可对脂溢性皮炎样皮肌炎进行早期诊断,早期积极联合糖皮质激素和免疫抑制剂治疗可以提高患者的生存率。

Seborrheic dermatitis-distributed dermatomyositis,a special type of dermatomyositis,is characterized by facial seborrheic dermatitis-distributed rashes,usually accompanied by Gottron papules,inverse Gottron papules,mechanic′s hands and skin ulcers,seldom accompanied by muscle involvement.Anti-melanoma differentiation-associated gene 5(MDA5)antibody-positive patients with seborrheic dermatitis-distributed dermatomyositis are prone to interstitial lung disease/rapidly progressive interstitial lung disease.Early diagnosis of seborrheic dermatitis-distributed dermatomyositis can be made through the combination of rashes and antibody detection,and early and active combined treatment with glucocorticoids and immunosuppressors can improve the survival rate of patients.