PLCD3基因rs12946454位点多态性与山东汉族人群子痫前期遗传易感性关系

ASSOCIATION OF PLCD3 GENE RS12946454 POLYMORPHISM WITH THE GENETIC SUSCEPTIBILITY TO PREECLAMPSIA IN THE CHINESE HAN POPULATION IN SHANDONG PROVINCE,CHINA

目的探讨磷脂酶Cδ3(PLCD3)基因rs12946454位点多态性与山东汉族人群子痫前期遗传易感性关系。方法用Taqman探针荧光定量PCR技术,对842例子痫前期病人以及1 013例正常妊娠妇女的PLCD3基因rs12946454位点进行基因型检测,比较两组基因型分布和等位基因频率的差异。结果子痫前期组与对照组PLCD3基因rs12946454位点基因型分布及等位基因频率差异无显著性(P>0.05)。轻度及重度子痫前期组、早发型及晚发型子痫前期组分别与对照组相比,PLCD3基因rs12946454位点基因型分布和等位基因频率差异均无统计学意义(P>0.05)。轻度子痫前期与重度子痫前期相比、早发型子痫前期与晚发型子痫前期相比,PLCD3基因rs12946454位点基因型和等位基因频率差异均无显著性(P>0.05)。结论 PLCD3基因rs12946454位点多态性可能与山东汉族人群子痫前期发病不相关。

Objective To investigate the association of PLCD3 gene rs12946454 polymorphism with the genetic susceptibility to preeclampsia in the Chinese Han population in Shandong province,China.Methods TaqMan probe real-time PCR was used to determine the genotype of PLCD3 gene rs12946454 in 842 patients with preeclampsia and 1013 normal pregnant women,and genotype distribution and allele frequencies were compared between the two groups.Results There were no significant differences in genotype distribution and allele frequencies of PLCD3 gene rs12946454 between the preeclampsia group and the control group(P>0.05).There were no significant differences in genotype distribution and alleles of PLCD3 gene rs12946454 between the mild/severe/early-onset/late-onset preeclampsia groups and the control group(P>0.05).There were no significant differences in genotype distribution and allele frequencies of PLCD3 gene rs12946454 between the mild preeclampsia group and the severe preeclampsia group,as well as between the early-onset preeclampsia group and the late-onset preeclampsia group(P>0.05).Conclusion The polymorphism of PLCD3 gene rs12946454 may not be associated with the onset of preeclampsia in the Chinese Han population in Shandong province.