肠道微生物制剂对小儿肠易激综合征肠道菌群、Th_(1)/Th_(2)细胞水平的影响

The effect of intestinal microbiological preparation on intestinal flora and Th1/Th2 cell level in children with irritable bowel syndrome

目的研究肠道微生物制剂对肠易激综合征(IBS)患儿肠道菌群和Th1/Th2细胞水平的影响。方法纳入2017年5月至2019年5月84例IBS患儿作为研究对象,采用随机数字表法将84例患儿分为观察组(n=42,常规治疗联合肠道微生物制剂)和对照组(n=42,常规治疗)。比较两组治疗效果,记录治疗前后肠道菌群计数和Th1/Th2细胞水平。结果观察组与对照组总有效率分别为97.62%与80.95%,两组间差异有统计学意义(P<0.05)。治疗后观察组患儿肠杆菌和肠球菌较治疗前均低于治疗前和对照组,双歧杆菌和乳酸杆菌均高于治疗前和对照组,差异均有统计学意义(P<0.05)。治疗后观察组IFN-γ和IFN-γ/IL-4均低于治疗前和对照组,IL-4均高于治疗前和对照组,差异均有统计学意义(P<0.05)。结论肠道微生物制剂用于IBS患儿有助于提高疗效,这可能与其改善肠道菌群水平,调节Th1/Th2细胞因子水平有关。

Objective To study the effect of intestinal microbiological preparation on intestinal flora and Th1/Th2 cell level in children with irritable bowel syndrome(IBS).Methods 84 children with IBS from May 2017 to may 2019 were as the research objects,and 84 children were divided into observation group(n=42,conventional treatment combined with intestinal microbiological preparation)and control group(n=42,conventional treatment)by random number table method.The effects of the two groups were compared,the intestinal flora count and Th1/Th2 cell level were recorded before and after treatment.Results The total effective rate of the observation group and the control group were 97.62%and 80.95%respectively,the difference between the two groups was statistically significant(P<0.05).The enterobacteria and enterococcus in the observation group after treatment were lower than those before treatment and the control group,the bifidobacteria and lactobacilli were higher than those before treatment and the control group,the difference were statistically significant(P<0.05).The IFN-γand IFN-γ/IL-4 in the observation group after treatment were lower than those before treatment and in the control group,and the IL-4 was higher than those before treatment and in the control group,the difference was statistically significant(P<0.05).Conclusion The intestinal microbiological preparation can improve the curative effect of IBS,which may be related to the improvement of intestinal microflora and the regulation of Th1/Th2 cytokines.