摘要
Objective:The current study involved an analysis of the characteristics of coronary artery lesions of patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and the correspond-ing influencing factors.Methods:One hundred twenty patients were selected by sleep apnea monitoring and coronary angiography.According to the apnea-hypopnea index(AHI),the patients were divided into the following 3 groups:patients with an AHI<10 times/h as the control group(n=25);patients with an AHI=10~15 times/h as the mild OSAHS group(n=32);and patients with an AHI>15 times/h as the moderate-to-severe OSAHS group(n=63).The clinical and laboratory test data of patients in each group were collected.A single-factor ANOVA and multi-factor logistic regression analysis were performed on the study data to analyze the coronary artery lesions in patients with OSAHS and the corresponding influencing factors.Results:(1)With respect to smoking,alcohol consumption,BMI,blood glucose,blood lipids,and blood pressure among the three groups,there were no significant differences between the three groups;however,age did differ among the three groups(P<0.05).(2)The incidence of anterior descending artery,right coronary artery,single-vessel,and coronary artery lesions as determined by coronary angiography was significantly different(P<0.05).The incidence of these vascular lesions in the moderate-to-severe group was higher than the mild group,and the incidence of coro-nary artery lesions in the moderate-to-severe group was higher(P<0.0167).(3)Based on multi-factor logistic regression analysis,alcohol consumption(OR=7.058;95%CI,1.953-25.508),age(OR=1.845;95%CI,1.121-3.038),and the AHI(OR=2.404;95%CI,1.088-5.314)were the major risk factors for coronary artery lesions.Alcohol consumption(OR=12.114;95%CI,3.058-47.979)and the AHI(OR=3.052;95%CI,1.210-7.694)were the risk factors for single-vessel disease.Age(OR=2.812;95%CI,1.236-6.400)was the major risk factor for multi-vessel disease.Conclusion:The probability of coronary artery lesions increased with OSAHS severity.The main manifestation of the increased possibility was single-vessel coronary artery lesions.In single-vessel disease,the anterior descending branch and the right coronary artery were the most vulner-able,which may be related to the anatomic distribution.Alcohol consumption,age,and AHI are the major risk factors for coronary artery lesions.Alcohol consumption and AHI are major risk factors for single-vessel disease.Age is the main risk factor for multi-vessel disease.
