摘要
During acute human immunodeficiency virus(HIV)infection,depletion of CD4^(+) T cells in the host gut mucosa occurs prior to its occurrence in the peripheral blood and other lymphoid tissues.Expression of integrinα4β7,a gut-homing receptor on CD4^(+) T cells,not only provides a potential receptor for HIV but also plays a critical role in lymphocyte migration from the circulation to the intestine.In our previous study,it was found that circulating gut-homingα4β7 CD4^(+) T cells,including the Th17 and Th1 subsets,were significantly depleted during acute HIV-1 infection.1 Moreover,no gut-homing Treg cells were depleted.Thus,the gut-homing Treg:Th17 ratio was inversely correlated with the CD4 T+cell count.
