益生菌干酪乳杆菌Zhang对大鼠空间学习记忆能力的影响

Effects of Lactobacillus casei Zhang on Spatial Learning and Memory of Rats

以益生菌干酪乳杆菌Zhang(LCZ)为研究对象,将20只雄性SD大鼠随机分为2组,即对照组(NC组)和LCZ组(4×10^(9) CFU/mL/d),通过Barnes迷宫试验测定成年大鼠到达目标洞的时间(潜伏期),探讨LCZ对大鼠空间学习记忆能力的影响。结果发现,在4 d的空间学习能力训练过程中,LCZ组大鼠潜伏期逐渐短于NC组,第3天起出现显著差异(95.63 s±86.78 s,P<0.05);在短期空间记忆的测试中,LCZ组大鼠潜伏期为(93.65±71.88)s,显著短于NC组(174.42 s±77.51 s,P<0.05)。以上结果表明,益生菌LCZ可以显著改善大鼠空间学习记忆能力。

In this study,Lactobacillus casei Zhang(LCZ)was used as the research object.Twenty male SD rats were randomly divided into two groups:the control group(NC group)and the LCZ group(4×10^(9) CFU/mL/d).The effect of LCZ on spatial learning and memory of rats was evaluated by the time(escape latency)of adult rats to reach the target hole during the Barnes maze test.The results showed that during the training of spatial learning for 4 days the escape latency of rats in the LCZ group was shorter than that in the NC group gradually,and a significant difference appeared on the 3rd day(95.63 s±86.78 s,P<0.05);The escape latency of LCZ group rats was(93.65±71.88)s,which was significantly shorter than that of NC group(174.42±77.51)s during the test of short-term spatial memeory(P<0.05).In summary,LCZ can significantly improve the spatial learning and memory of rats.