玫瑰枸杞发酵饮品对大鼠耳廓微循环的改善作用

The Effect of the Fermented Beverage of Rose rugosa cv.Plena and Lycium barbarum L.on the Auricle Microcirculation in Rats

目的:探讨受试样品“玫瑰枸杞发酵饮品”对雌性大鼠耳廓微循环的改善作用。方法:将实验动物按其体重随机分为4组:空白对照组、玫瑰枸杞发酵饮品低剂量组、中剂量组和高剂量组,其中空白对照组灌胃去离子水。采用激光多普勒血流仪观测玫瑰枸杞发酵饮品分别对大鼠耳廓微循环在正常状态和高分子右旋糖酐所致微循环障碍状态下血流灌注量的影响。结果:在正常情况下,受试样品在灌胃14 d时即能显著提升(P<0.05)大鼠微循环血流灌注量,并长效稳定保持其提升血流灌注量的功能至30 d。同时在微循环障碍模型中,显著减轻(P<0.05)高分子右旋糖酐所致SD大鼠微血管收缩效应,改善微循环障碍。结论:玫瑰枸杞发酵饮品对雌性大鼠耳廓微循环有一定的改善作用。

Objective:To investigate the effect of the sample"fermented beverage of Rose rugosa cv.Plena and Lycium barbarum L."on the auricle microcirculation in female rats.Methods:The experimental animals were randomly divided into four groups according to their body weight:normal control group,low-,medium-and high-dose group of fermented beverages.The normal control group was given deionized water by intragastric administration.Laser Doppler blood flow meter was used to observe the perfusion unit(PU)of rat auricle microcirculation by the effect of the beverage in normal state and microcirculation disturbance caused by high molecular dextran.Results:Under the normal conditions,the blood flow perfusion and velocity of microcirculation in rats were significantly increased after 14 days of intragastric administration(P<0.05),and the function of enhancing blood flow perfusion was maintained thereafter until 30 days.Meanwhile,in the model of microcirculatory disturbance,the microvascular contraction effect of SD rats induced by high molecular dextran was significantly reduced(P<0.05),and microcirculatory disturbance was improved.Conclusion:The fermented beverage of Rose rugosa cv.Plena and Lycium barbarum L.can improve the auricle microcirculation in female rats.