HPV16 E7乳酸乳球菌疫苗联合顺铂抗肿瘤效果研究

Antitumor Effect of Cisplatin Combined with HPV16 E7 Lactococcus Lactis Vaccine

探索HPV16 E7乳酸乳球菌疫苗联合化疗药物顺铂治疗HPV16相关肿瘤的效果.荷瘤小鼠使用顺铂或联合乳酸乳球菌疫苗治疗后,通过荷瘤小鼠肿瘤大小、生存率、体重变化和血清中IL-10、IL-12、IFN-γ水平评价化疗药物顺铂与乳酸乳球菌疫苗单独使用及联用的抗肿瘤效果差异.顺铂与乳酸乳球菌疫苗联合治疗能抑制荷瘤小鼠体内肿瘤生长、延长小鼠生存时间,但治疗组间差异并不显著.顺铂与疫苗联用具有增强抗肿瘤效果的潜力.

This paper explores the effect of human papillomavirus(HPV)16 E7 Lactococcus lactis vaccine combined with cisplatin on HPV16 related tumors.Tumor-bearing mice were treated with cisplatin or/and L.lactis vaccine,respectively.The antitumor effect was evaluated among cisplatin alone,L.lactis vaccine alone or their combination by tumor size,survival rate,mouse weight and the levels of IL-10,IL-12 and INF-γin sera.Cisplatin,L.lactis vaccine or combination therapy could inhibit tumor growth and prolong the survival time of tumor mice,but there was no significant difference among the treatment groups.The combination of cisplatin and L.lactis vaccine has the potential to enhance the anti-tumor effect.