注射用头孢曲松钠临床配伍稳定性研究

The Stability of Ceftriaxone Sodium for Injection for Clinical Compatibility

目的考察注射用头孢曲松钠在与临床常用输液配伍后稳定性。方法从关键质量属性:有关物质、含量测定、聚合物、pH值、溶液颜色评价配伍后稳定性。结果注射用头孢曲松钠配伍后在室温6 h下稳定。结论注射用头孢曲松钠在输液中稳定性有限,为了保证用药安全,应引起临床用药注意。

OBJECTIVE The essay is to investigate the stability of ceftriaxone sodium for injection after compatibility with clinical common infusion.METHODS The compatibility stability was evaluated in terms of the critical quality attributes such as related substances,content assay,polymers,colours of solution.RESULTS Ceftriaxone sodium for injection was stable at room temperature for 6 hours after compatibility.CONCLUSION The stability of ceftriaxone sodium for injection is limited in other injection.Therefore,in order to ensure drug safety,clinical medication should be paid special attention to.