发疱法移植测试提高自体表皮细胞移植技术治疗白癜风疗效的临床意义

Clinical significance of suction blister transplantation in improving efficacy of ReCell technique in treatment of vitiligo

目的探讨发疱法移植技术在提高自体表皮细胞移植(ReCell)技术治疗白癜风疗效的临床意义。方法2015年1月至2018年12月,北京协和医院整形外科将白癜风患者90例(男59例,女31例;年龄17~51岁,平均27岁)分为3个组,每组30例,分别为无发疱法治疗史白癜风患者组(对照组),发疱法无效患者组(治疗1组)、发疱法有效患者组(治疗2组)。均接受标准流程的ReCell技术治疗。观察术后3、6个月患者白斑的复色效果,同时观察并发症的发生情况。结果术后3、6个月白癜风患者复色有效率>50.0%,无发疱法治疗史白癜风患者组分别是53.3%、63.3%;发疱法无效患者组分别是43.3%、50.0%;发疱法有效患者组分别是76.7%、90.0%。3个组均无明显手术并发症。结论ReCell技术治疗稳定期白癜风,发疱法是筛选患者的一种简单有效的方法。

Objective To investigate the clinical significance of suction blister transplantation in improving the efficacy of ReCell technique in the treatment of vitiligo.Methods Patients were divided into three groups,namely,vitiligo patients without history of suction blister therapy,patients with ineffective suction blister therapy and patients with effective suction blister therapy.There were 30 patients in each group.All patients were treated with standard procedure of ReCell technique.The color recovery effect of leukoplakia was observed 3 and 6 months after operation,and the incidence of complications was also observed.Results The effective rate of color recovery 3 and 6 months after operation were as follow:in patients without history of suction blister group,the effective rate of three months was 53.3%,and that of six months was 63.3%;in patients with ineffective suction blister group,the effective rate was 43.3%in three months and 50.0%in six months,and in patients with effective suction blister group,the effective rate was 76.7%in three months and 90.0%in six months.No obvious complications were observed in the three groups.Conclusions For the treatment of stable vitiligo with ReCell technique,suction blister method is a simple and effective method for screening patients.