基于文献分析心肺复苏后脑功能障碍的中医证型分布及用药规律

An Analysis of Distribution of Chinese Medicine Syndrome Types and Administration Rules of Brain Dysfunction After Cardiopulmonary Resuscitation Based on Literature

目的:通过分析相关文献,总结心肺复苏后脑功能障碍的中医证型分布及用药规律。方法:采用“心肺复苏后脑功能障碍”或“复苏后脑功能障碍”或“复苏后脑损伤”或“脑功能障碍”或“脑损伤”或“心搏骤停后脑复苏”和主题词“中医”或“中药”或“中药治疗”或“中医治疗”或“中医证型”或“证候”,在中国知网(CNKI)、维普、万方进行检索,根据纳入排除标准最终筛选文献24篇,将数据整理录入Excel 2007,并应用SPSS19.0统计软件进行分析。结果:中医证型出现频次前3位是阳气暴脱型、气虚血瘀型和气阴两脱型。方剂/中成药应用频次前3位分别是参附注射液、生脉注射液及川芎嗪注射液。单味中药的应用频次前6位分别是红参、附子、川芎、麦冬、五味子及当归。聚类分析显示了4组药物:①黄芩、板蓝根、珍珠母、水牛角、金银花;②川芎、赤芍、红花、当归、丹参、桔梗、柴胡、枳壳、人参、牛膝、生地黄;③麝香、冰片、栀子、郁金;④牛黄、黄连、朱砂、珍珠、雄黄。结论:心肺复苏后脑功能障碍的中医证型以虚证为主,用药多为补益类中成药注射液和中药,清热解毒类、活血化瘀类和解毒醒神类中药也有一定作用。

Objective:To summarize the distribution of Chinese medicine syndrome types and administration rules of brain dysfunction after cardiopulmonary resuscitation(CPR)by analyzing relevant literature.Methods:Keywords including“brain dysfunction after CPR”,“brain dysfunction after resuscitation”,“brain damage after resuscitation”,“brain dysfunction”,“brain damage”,“brain resuscitation after cardiac arrest”,“Chinese medicine”,“Chinese herbs”,“Chinese herbal treatment”,“Chinese medicine treatment”,“Chinese medicine syndrome type”or“syndrome”,were retrieved in CNKI,VIP and Wanfang databases.According to the inclusion and exclusion criteria,24 pieces of literature were finally screened,and the data were sorted into Excel 2007 and analyzed by SPSS19.0 statistical software.Results:The top three Chinese medicine syndrome types were the sudden desertion of yang qi type,qi deficiency and blood stasis type and desertion of both qi and yin type.The top three prescriptions or Chinese patent medicine were Shenfu injection,Shengmai injection and Ligustrazine injection.The top six single Chinese herbs in terms of application frequency were Radix et Rhizoma Ginseng Rubra,Radix Aconiti Lateralis Praeparata,Rhizoma Chuanxiong,Radix Ophiopogonis,Fructus Schisandrae Chinensis and Radix Angelicae Sinensis.Cluster analysis showed four herb combinations:(1)Radix Scutellariae,Radix Isatidis,Concha Margaritiferae Usta,Cornu Bubali,Flos Lonicerae Japonicae;(2)Rhizoma Chuanxiong,Radix Paeoniae Rubra,Flos Carthami,Radix Angelicae Sinensis,Radix et Rhizoma Salviae Miltiorrhizae,Radix Platycodonis,Radix Bupleuri,Fructus Aurantii,Radix et Rhizoma Ginseng,Radix Achyranthis Bidentatae,Radix Rehmanniae;(3)Moschus,Borneolum Syntheticum,Fructus Gardeniae,Radix Curcumae;(4)Calculus Bovis,Rhizoma Coptidis,Cinnabaris,Margarita,Realgar.Conclusion:Deficiency syndrome is the main type of Chinese medicine syndrome types after CPR.Most herbs in application are tonic Chinese patent medicine injection and Chinese herbs,and Chinese medicine of clearing heat and detoxification,promoting blood circulation and removing blood stasis and detoxification and reviving mind also have certain effects.