益气补肺汤联合西药治疗冠心病肺虚血瘀型临床研究

Clinical Study on Yiqi Bufei Tang Combined with Western Medicine for Coronary Heart Disease of Lung Deficiency and Blood Stasis Type

目的:观察益气补肺汤联合西医治疗冠心病肺虚血瘀型患者的临床疗效。方法:选择2016年6月—2018年4月收治的50例肺虚血瘀型冠心病患者,分别采用常规西药(对照组,25例)和益气补肺汤联合西药(治疗组,25例)进行治疗,比较2组中医证候积分、美国纽约心脏病协会(NYHA)分级、B型钠尿肽(BNP)含量、血脂水平、心电图变化、左心室功能、临床疗效和不良反应。结果:治疗后,治疗组NYHA改善情况显著优于对照组(Z=-2.060,P<0.05);中医证候改善大于对照组(P<0.05)。ST-T改变、房性早搏、室性早搏、房室传导阻滞情况低于对照组(P<0.05)。治疗前2组BNP、总胆固醇(TC)、甘油三酯(TG)水平比较,差异无统计学意义(P>0.05);治疗后,治疗组BNP及血脂水平较前改善(P<0.05),对照组TC与治疗前比较,差异无统计学意义(P>0.05)。治疗组治疗后BNP、TC、TG水平远远低于对照组(P<0.05)。治疗前2组左心室射血分数(LVEF)、每搏指数(SI)、心排量(CO)水平比较,差异无统计学意义(P>0.05);治疗后2组LVEF、SI、CO均显著高于治疗前,治疗组LVEF、SI、CO显著高于对照组(P<0.05)。治疗组疗效(92.00%)优于对照组(68.00%)(P<0.05)。结论:益气补肺汤联合西医治疗肺虚血瘀型冠心病患者能有效缓解各种症状,疗效确切。

Objective:To observe the clinical effect of the therapy of Yiqi Bufei tang combined with western medicine for patients with coronary heart disease of lung deficiency and blood stasis type.Methods:A total of 50 cases of patients with coronary heart disease of lung deficiency and blood stasis type who were admitted from June 2016 to April 2018 were selected,and were divided into the control group and the treatment group,25 cases in each group.The control group was given routine western medicine,and the treatment group was given Yiqi Bufei tang and western medicine.Chinese Medicine Syndrome Scale,New York Heart Association(NYHA)classification,the content of B-type natriuretic peptide(BNP),the level of blood lipid,change in electrocardiogram,left ventricle function,the clinical effect,and adverse reactions were compared between the two groups.Results:There was no significant difference being found in the comparison of grading of the heart function between the two groups before treatment(P>0.05).After treatment,grading of the heart function in the two groups was improved when compared with that before treatment(P<0.05),and the NYHA improvement in the treatment group was significantly better than that in the control group(Z=-2.060,P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were improved when compared with those before treatment,and the improvement in the treatment group was better than that in the control group(P<0.05).There was no significant difference being found in the comparison of condition of electrocardiogram between the two groups before treatment(P>0.05).After treatment,the condition of electrocardiogram in the two groups was improved when compared with that before treatment;the incidence of abnormal ST-T,premature atrial contraction,premature ventricular contraction,and atrioventricular block in the treatment group was far lower than that in the control group(P<0.05).Before treatment,when compared levels of BNP,total cholesterol(TC),and triglyceride(TG)between the two groups,there was no significance being found in the difference(P>0.05).After treatment,levels of BNP and blood lipid in the treatment group were improved when compared with those before treatment(P<0.05);in the control group,there was no significant difference being found in the comparison of TC level after treatment and that before treatment.After treatment,levels of BNP,TC,and TG in the treatment group were far lower than those in the control group(P<0.05).Before treatment,when compared levels of left ventricular ejection fraction(LVEF),stroke index(SI),and cardiac output(CO)between the two groups,there was no significance being found in the difference(P>0.05).After treatment,levels of LVEF,SI,and CO in the two groups were significantly higher than those before treatment,and the three levels in the treatment group were far higher than those in the control group(P<0.05).The total clinical effective rate was 92.00%in the treatment group,significantly higher than that of 68.00%in the control group(P<0.05).Conclusion:In the treatment of patients with coronary heart disease of lung deficiency and blood stasis type,the therapy of Yiqi Bufei tang combined with western medicine effectively relieves various symptoms,with defined curative effect.