通腑宣肺汤联合无创机械通气治疗慢性阻塞性肺疾病急性加重期临床研究

Clinical Study of Tongfu Xuanfei Tang Combined with Noninvasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:观察通腑宣肺汤联合无创机械通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:选择收治的84例AECOPD住院患者作为研究对象,将其随机分为2组各42例。对照组应用包括无创机械通气的西医常规治疗,观察组在对照组治疗方案的基础上加用通腑宣肺汤,比较2组临床疗效、C-反应蛋白(CRP)、动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)和腹胀的情况。结果:临床疗效总有效率观察组90.48%,对照组80.95%,差异有统计学意义(P<0.05)。治疗后,2组CRP、PaO2及PaCO2分别与治疗前比较,差异均有统计学意义(P<0.05);2组间比较,差异均有统计学意义(P<0.05),且观察组优于对照组。治疗后,观察组腹胀发生率明显低于对照组,差异有统计学意义(P<0.05),2组治疗期间均无明显不良反应发生。结论:通腑宣肺汤联合无创机械通气在治疗AECOPD中效果显著,可有效改善症状和血气分析,明显减轻腹胀。

Objective:To observe the clinical effect of Tongfu Xuanfei tang combined with noninvasive ventilation for acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:A total of 84 cases of inpatients with AECOPD were selected as the study subjects and randomly divided into two groups,42 cases in each group.The controlgroup was treated with routine western medicine treatment including noninvasive ventilation,and the observation group was additionally treated with Tongfu Xuanfei tang based on the treatment of the control group.The clinical effect,C-reactive protein(CRP),arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2)and abdominal distention in the two groups were compared.Results:The total clinical effective rate was 90.48%in the observation group and 80.95%in the control group,the difference being significant(P<0.05).After treatment,the values of CRP,PaO2 and PaCO2 in the two groups compared with those before treatment,differences being significant(P<0.05);and the above values in the observation group were better than those in the control group,differences being significant(P<0.05).After treatment,the incidence of abdominal distension in the observation group was significantly fewer than that in the control group,the difference being significant(P<0.05).During treatment,no obvious adverse reaction occurred in the two groups.Conclusion:The therapy of Tongfu Xuanfei tang combined with noninvasive ventilation has significant effect in treating AECOPD,which can effectively improve symptoms and blood gas analysis,and significantly reduce abdominal distension.