摘要
The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3)inflammasome is one of the pattern recognition receptors for host defense against pathogen-associated molecular patterns and danger-associated molecular patterns.The NLRP3 inflammasome is a best characterized as a multiprotein complex composed of NLRP3,apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC)adaptor,and pro-caspase-1.The NLRP3 inflammasome is activated by select activators or pathogen stimuli,and a conformational change of inflammasome-forming NOD-like receptor(NLR)enables NLR binding to ASC via pyrin domains.
