孕期增重与儿童肥胖的研究进展

Progress in research on relationship between gestational weight gain and childhood obesity

识别生命早期危险因素对肥胖防控关口前移尤为重要和紧迫。该文通过梳理队列与干预研究,对母亲孕期增重与儿童肥胖的研究现况进行了总结。在队列研究中,母亲孕期增重过多可能增加儿童在学龄前期、学龄期、青春期和青少年时期发生肥胖的风险,但孕期增重与儿童肥胖的关联可能受到遗传背景等混杂偏倚的影响,尚需要更多对照研究阐明二者的因果关系。在随机对照研究中,孕期生活方式干预可预防孕期增重过多,但在预防儿童肥胖中的作用尚不明确。该文从孕期增重与儿童肥胖的关联、因果关系,以及孕期干预对儿童肥胖的作用多个角度,综述了孕期增重与儿童肥胖研究方面的进展,以期为探索儿童肥胖的发病机制和肥胖防控措施前移提供科学依据。

It is important and urgent to identify early-life risk factors of obesity for putting forward the fort of preventing and controlling childhood obesity.This study summarizes current evidences from cohort and interventional studies on relationship between gestational weight gain(GWG) and childhood obesity.In cohort studies, excessive GWG might increase the risk of obesity in stages of pre-school age, school age, adolescent and juvenile.Notably, the associations of GWG and childhood obesity might be confounded by factors like genetic background, so more sibling-control studies are needed to elucidate the causal relationship between GWG and childhood obesity.In randomized controlled studies, lifestyle interventions in pregnancy can prevent excessive GWG,but its role in preventing childhood obesity is still unclear.This study reviews the association of GWG with childhood obesity, their causal relationship, and the effect of pregnancy interventions on childhood obesity, aiming to provide scientific evidence in mechanism and prevention strategies of childhood obesity.