老年高甘油三酯血症患者血清上皮型钙粘蛋白、β-连环蛋白、肌球蛋白轻链激酶水平变化与急性胰腺炎发生的相关性分析

Thecorrelation between changes of levels of serum E-cadherin,β-catenin and MLCK and the occurrence of acute pancreatitis in elderly patients with hypertriglyceridemia

目的分析老年高甘油三酯血症(HTG)患者血清上皮型钙粘蛋白(E-cadherin)、β-连环蛋白(β-catenin)、肌球蛋白轻链激酶(MLCK)水平变化与急性胰腺炎(AP)发生的相关性。方法我院86例HTG并发AP老年患者(HTG+AP组)及48例HTG非AP老年患者(HTG组)。比较两组基线资料及血清E-cadherin、β-catenin、MLCK水平差异,评估血清E-cadherin、β-catenin、MLCK水平对HTG并发AP的诊断价值,分析HTG并发AP老年患者病情严重程度与血清E-cadherin、β-catenin、MLCK水平的相关性。结果两组性别、年龄及高血压、糖尿病患病率比较,差异无统计学意义(P>0.05);HTG+AP组甘油三酯、总胆固醇、血清E-cadherin、β-catenin、MLCK水平高于HTG组(P<0.05)。血清E-cadherin、β-catenin、MLCK水平对HTG并发AP均具有较高诊断价值(P<0.05)。HTG+AP组中,轻症者血清E-cadherin、β-catenin、MLCK水平低于中重症及重症者,中重症者低于重症者(P<0.05)。HTG并发AP老年患者血清E-cadherin、β-catenin、MLCK水平与病情严重程度呈正相关(P<0.05)。结论E-cadherin、β-catenin、MLCK可能参与HTG性AP的发生、发展,血清含量在HTG并发AP老年患者中均显著升高,有望成为HTG性AP诊疗新指标。

Objective To analyze the correlation between changes of serum epithelial cadherin(E-cadherin),β-catenin(β-catenin)and myosin light-chain kinase(MLCK)and theoccurrence of acute pancreatitis(AP)in elderly patients with hypertriglyceridemia(HTG).Methods The clinical data of 86 elderly patients with HTG and AP(HTG+AP group)and 48 elderly patients with HTG but without AP(HTG group)were retrospectively reviewed.The baseline data and levels of serum E-cadherin,β-catenin and MLCK were compared between the two groups.The diagnostic value of levels of serum E-cadherin,β-catenin,and MLCK for HTG with AP was evaluated.The correlation between disease severity and levels of serum E-cadherin,β-catenin and MLCK was analyzed among elderly patients with HTG and AP.Results There were no significant differences in gender,age and prevalence rates of hypertension and diabetes mellitus between the two groups(P>0.05).The levels of triglyceride,total cholesterol,E-cadherin,β-catenin and MLCK in the HTG+AP group were significantly higher than those in the HTG group(P<0.05).After ROC curve analysis,it was found that levels of serum E-cadherin,β-catenin and MLCK had high diagnostic valuesfor HTG with AP(P<0.05).Among elderly patients with HTG and AP,the levels of serum E-cadherin,β-catenin and MLCK in mild patients were significantly lower than those in moderate-to-severe patients and severe patients(P<0.05),and the levels in moderate-to-severe patients were lower than those in severe patients(P<0.05).Spearman rank correlation analysis showed that levels of serum E-cadherin,β-catenin and MLCK in elderly patients with HTG complicated with AP were positively correlated with the severity of disease(P<0.05).Conclusion E-cadherin,β-catenin and MLCK may be involved in the occurrence and development of HTG with AP.Serum levels are significantly increased in elderly patients with HTG complicated with AP,and they are expected to become the new indicators for the diagnosis and treatment of HTG with AP.