摘要
The Zika virus(ZIKV)is an arbovirus in the same family,Flaviviridae,as the dengue virus(DENV),the West Nile virus,the yellow fever virus,and the Japanese encephalitis virus.ZIKV has been a recent research focus because of its close association with severe human diseases and syndromes,particularly congenital Zika syndrome,which includes fetal microcephaly and other brain abnormalities.1 The ZIKV envelope(E)protein is a major structural protein involved in receptor binding,viral entry,and fusion.It is arranged as a dimer,with each monomer consisting of three domains(DI,DII,and DIII),a stem region,and a transmembrane region.2 The ZIKV E protein induces the production of potent neutralizing antibodies against ZIKV and is thus a key target for the development of therapeutic ZIKV antibodies.
