舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者的效果研究

Effect of Sertraline in the Treatment of Chronic Obstructive Pulmonary Disease Patients with Anxiety and Depression

目的观察舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者临床治疗效果。方法选取2018年2月~2020年8月在我院诊治的72例合并焦虑抑郁的慢性阻塞性肺疾病患者为研究对象,采用随机数字表法分为对照组和观察组,各36例。对照组采用常规治疗,观察组在常规治疗基础上联合舍曲林治疗,比较两组肺功能指标、焦虑和抑郁评分、血气指标、6 min步行试验距离、生活质量以及不良反应发生情况。结果治疗后,两组FEV1、FVC、PEF均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后两组焦虑、抑郁评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PaCO_(2)低于治疗前,PaO_(2)、SaO_(2)水平均高于治疗前,且观察组PaCO_(2)低于对照组,PaO_(2)、SaO_(2)水平高于对照组,差异有统计学意义(P<0.05);干预后,两组6 min步行试验距离、生活质量评分均大于干预前,且观察组大于对照组(P<0.05);观察组不良反应发生率为8.33%,与对照组的11.11%比较,差异无统计学意义(P>0.05)。结论舍曲林治疗合并焦虑抑郁的慢性阻塞性肺疾病患者效果确切,可改善患者肺功能和血气指标,减轻抑郁和焦虑症状,提高患者运动功能,提升生活质量,且不会增加临床不良反应。

Objective To observe the clinical treatment of patients with chronic obstructive pulmonary diseases in the treatment of combined anxiety and depression.Methods 72 patients with chronic obstructive pulmonary disease combined with anxiety and depression were treated in our hospital from February 2018 to August 2020,Using random number table method,they were divided into control group and observation group,each with 36 cases.The control group was treated with conventional treatment,and the observation group was treated with sertraline on the basis of conventional treatment.The pulmonary function indexes,anxiety and depression scores,blood gas indexes,6-min walk test distance,quality of life,and adverse reactions were compared between the two groups.Results After treatment,the FEV1,FVC,and PEF of the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);After treatment,the anxiety and depression scores of the two groups were lower than those before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);After treatment,PaCO_(2) in the two groups was lower than before treatment,PaO_(2) and SaO_(2) levels were higher than before treatment,PaCO_(2) in the observation group was lower than that in the control group,PaO_(2) and SaO_(2) levels were higher than in the control group,the difference was statistically significant(P<0.05);After the intervention,the 6-min walking test distance and quality of life scores of the two groups were greater than those before the intervention,and the observation group was greater than the control group(P<0.05);The incidence of adverse reactions in the observation group was 8.33%,compared with 11.11%in the control group,the difference was not statistically significant(P>0.05).Conclusion Sertraline is effective in treating chronic obstructive pulmonary disease patients with anxiety and depression.It can improve patients'lung function and blood gas indicators,reduce symptoms of depression and anxiety,improve patients'motor function,improve quality of life,and will not increase clinical adverse reactions.