奥美沙坦酯和坎地沙坦酯治疗原发性高血压的效果

Comparison of the Effects of Olmesartan Medoxomil and Candesartan Cilexetil in the Treatment of Essential Hypertension

目的观察奥美沙坦酯和坎地沙坦酯治疗原发性高血压的效果并比较。方法选取我院2019年1月~2020年12月进行治疗的90例原发性高血压为研究对象,按照随机数字法为对照组与研究组,每组45例。对照组采用坎地沙坦酯治疗,研究组服用奥美沙坦酯治疗。比较两组治疗前后的的血压、心率、心电图和血、尿常规、动态血压、血压平滑指数(SI)及疗效。结果治疗后两组血压低于治疗前,研究组低于对照组,差异有统计学意义(P<0.05);治疗后两组收缩压平滑指数(SISBP)、舒张压平滑指数(SIDBP)均高于治疗前,差异有统计学意义(P<0.05),组间比较,差异无统计学意义(P>0.05);研究组治疗总有效率为84.44%,与对照组的80.00%比较,差异无统计学意义(P>0.05)。结论奥美沙坦酯和坎地沙坦酯治疗原发性高血压疗效相当,但奥美沙坦酯SI更高,血压变异性更低。

Objective To observe and compare the effects of olmesartan medoxomil and candesartan medoxomil in the treatment of essential hypertension.Methods A total of 90 cases of essential hypertension who were treated in our hospital from January 2019 to December 2020 were selected as the research objects,and the control group(n=45)and the study group(n=45)were selected according to the random number method.The control group was treated with candesartan cilexetil and the study group was treated with olmesartan medoxomil.The blood pressure,heart rate,electrocardiogram,blood,urine routine,ambulatory blood pressure,blood pressure smoothing index(SI)and curative effect of the two groups before and after treatment were compared.Results After treatment,the blood pressure of the two groups was lower than before treatment,and the study group was lower than the control group,the difference was statistically significant(P<0.05);After treatment,the systolic blood pressure smoothing index(SISBP)and diastolic blood pressure smoothing index(SIDBP)were higher than before treatment,the difference was statistically significant(P<0.05).There was no statistically significant difference between the groups(P>0.05);The total effective rate of treatment in the study group was 84.44%,compared with 80.00%in the control group,the difference was not statistically significant(P>0.05).Conclusion Olmesartan medoxomil and candesartan cilexetil have equivalent efficacy in the treatment of essential hypertension,but olmesartan medoxomil has a higher SI and lower blood pressure variability.