脂代谢紊乱在糖尿病肾脏疾病发病机制中的研究进展

The progress of dyslipidemia in pathogenesis of diabetic kidney disease

DKD患者常伴血脂紊乱,脂质调控与DKD发生发展密切相关。脂质通过沉积、脂质修饰、促发炎症反应、诱导IR、促进细胞凋亡等多种途径,参与DKD发生发展。本文对脂代谢紊乱在DKD发病机制中的研究进展进行综述,旨在为临床治疗DKD提供依据。

Diabetic kidney disease(DKD)patients are often accompanied with dyslipidemia.Lipid regulation is closely related to the occurrence and development of DKD.Lipid is involved in kidney injury and progression of DKD through deposition,lipid modification,inflammation,insulin resistance and apoptosis.This article reviews the research progress of lipid metabolism disorders in the pathogenesis of DKD in order to provide the basis for clinical treatment of DKD.