注重肝病标志物及其模型算法应用:实践与展望

Emphasis on the biomarkers of liver diseases and the application of its algorithm application:practice and prospect

血液标志物检测是最为方便、经济适用的疾病筛查和动态监测手段。本文聚焦终末期肝病-肝硬化和肝癌标志物,从临床常用基础检验到新型标志物的发现和转化应用,阐述了肝病标志物的分类、新型标志物研究、转化和诊断模型应用以及肝病标志物及其算法研究中应关注的问题。注重基于模型算法的多个标志物有效联合是实现以原发性肝癌为代表的终末期肝病临床精准诊疗、高危预警并全程精准管理的重要手段。

Circulation biomarker detection is one of the most feasible options for disease screening and monitoring.Focusing on the biomarkers of end stage liver diseases(liver cirrhosis and hepatocellular carcinoma),this article summarized the classification of biomarkers,the exploration and translation of new biomarkers,as well as the applications of the algorithms of the biomarkers.The key points involved in both new biomarker exploration and algorithm construction were addressed.The comprehensive application of available markers,using algorithms,is strongly recommended and should be strengthened in the future for precise clinical management and high-risk predictions in diseases such as hepatocellular carcinoma.