摘要
抗N-甲基-D-天冬氨酸受体(anti-N-methyl D-aspartate receptor,抗NMDAR)脑炎是由抗NMDAR抗体介导的自身免疫性脑炎,在成人与儿童均可发病,儿童抗NMDAR脑炎在诱因、临床表现、诊断流程、治疗随访策略和预后均有别于成人,有其独自的特点。本病虽然临床表现重,但给予及时和有效的免疫治疗,可使绝大部分患儿获得良好预后。为此,本文总结分析本病的治疗进展,以期提高我国儿科医生对儿童抗NMDAR脑炎的规范化诊疗水平,降低致残和致死率。
Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis is an autoimmune disorder mediated by anti-NMDAR antibody.It can be found in both adults and children.Anti-NMDAR encephalitis in children is different from adults in inducement,clinical manifestation,diagnosis process,treatment,follow-up strategy,and prognosis.Although the clinical manifestation of the disease is serious,timely and effective immunotherapy can make the vast majority of children get a good prognosis.Therefore,the review summarized and analyzed the treatment progress,in order to improve the standard diagnosis and treatment of pediatric anti-NMDAR encephalitis in China,and reduce the morbidity and mortality.
作者
彭镜
钟林秀
Peng Jing;Zhong Linxiu(Department of Pediatrics,Xiangya Hospital of Central South University,Changsha 410008,China)
出处
《中国小儿急救医学》
CAS
2021年第6期453-457,共5页
Chinese Pediatric Emergency Medicine