儿童自身免疫性癫痫

Pediatric autoimmune epilepsy

随着免疫性因素在癫痫病因中的确立,癫痫与免疫的关系逐渐成为了研究的热点。自身免疫性癫痫是一种尚未得到充分认识的疾病,但确定癫痫潜在的自身免疫性病因至关重要。由于自身免疫性癫痫对传统的抗癫痫药物治疗反应欠佳,而可能对免疫治疗有效。因此,及时、准确地诊断和免疫治疗干预是改善患儿预后的重要因素。目前,关于儿童自身免疫性癫痫的研究有限,本文就儿童自身免疫性癫痫的概念演变、流行病学、临床表现、发病机制、诊断及治疗的进展作简要阐述。

With the establishment of immune factors in the causes of epilepsy,the relationship between epilepsy and immunity has gradually become the focus of research.Autoimmune epilepsy has not been fully understood,but it is critical to identify the potential autoimmune etiology for epilepsy.Autoimmune epilepsy often does not respond well to conventional antiepileptic treatment but may be effective for immunotherapy.Therefore,timely and accurate diagnosis as well as immunotherapy intervention are important factors to improve the prognosis of children with autoimmune epilepsy.At present,limited studies are available about autoimmune epilepsy in children.We briefly reviewed the concept evolution,epidemiology,clinical features,pathogenesis,diagnosis and treatment of autoimmune epilepsy in children.