摘要
The Hippo signaling pathway has been established as a key regulator of organ size control,tumor suppression,and tissue regeneration in multiple organisms.Recently,emerging evidence has indicated that Hippo signaling might play an important role in regulating the immune system in both Drosophila and mammals.In particular,patients bearing a loss-of-function mutation of MST1 are reported to have an autosomal recessive primary immunodeficiency syndrome.MST1/2 kinases,the mammalian orthologs of Drosophila Hippo,may activate the non-canonical Hippo signaling pathway via MOB1A/B and/or NDR1/2 or cross-talk with other essential signaling pathways to regulate both innate and adaptive immunity.In this review,we present and discuss recent findings of cellular mechanisms/functions of Hippo signaling in the innate immunity in Drosophila and in mammals,T cell immunity,as well as the implications of Hippo signaling for tumor immunity.
基金
This work was supported by grants from National Key R&D Program of China(2017YFA0504502 to D.Z.and L.C.,2015CB910502 to L.C.)
The National Natural Science Foundation of China(U1405225 to L.C.,31625010,81790254,and U1505224 to D.Z.,81472229 to L.H.,81302529 to X.L.)
the Fundamental Research Funds for the Central Universities of China-Xiamen University(20720180047 to L.C.,20720160071 to D.Z.,and 20720160054 to L.H.).
