Induction of human dendritic cell maturation by naïve and memory B-cell subsets requires different activation stimuli

Dendritic cells(DCs)are the master regulators of the immune response and engage in constant cross-talk with other immune cells to initiate an appropriate immune response.The outcome of cross-talk with various immune cells towards DC functions has been shown to be dependent on the particular subset of cells and their activation stimuli.Here we show that for human B cells to induce maturation of DCs with an enhanced T-cell stimulatory capacity,B-cell receptor(BCR)signaling is sufficient for memory B-cells,whereas additional CD40 signaling is required for naïve B cells to induce complete activation of DCs.