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Alzheimer’s disease hypothesis and related therapies 被引量：10

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摘要 Alzheimer’s disease(AD)is a progressive neurodegenerative disorder and the most common cause for dementia.There are many hypotheses about AD,including abnormal deposit of amyloidβ(Aβ)protein in the extracellular spaces of neurons,formation of twisted fibers of tau proteins inside neurons,cholinergic neuron damage,inflammation,oxidative stress,etc.,and many anti-AD drugs based on these hypotheses have been developed.In this review,we will discuss the existing and emerging hypothesis and related therapies.
作者 Xiaoguang Du Xinyi Wang Meiyu Geng
机构地区 Shanghai GreenValley Pharmaceutical Co. State Key Laboratory of Drug Research
出处 《Translational Neurodegeneration》 SCIE CAS 2018年第1期9-15,共7页 转化神经变性病（英文）
基金 This review was supported by“Personalized Medicines-Molecular Signature based Drug Discovery and Development”,Strategic Priority Research program of Sciences,Grants No.XDA12040101.
关键词 Alzheimer’s disease-complicated disease-anti-AD drugs Hypothesis about AD
分类号 R74 [医药卫生—神经病学与精神病学]
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Translational Neurodegeneration
2018年 第1期

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