阿替普酶联合依拉达奉治疗老年脑梗死的临床效果

Clinical effect of alteplase combined with edaravone in the treatment of elderly cerebral infarction

目的分析阿替普酶联合依拉达奉治疗老年脑梗死的临床效果。方法选取2019年1月至2020年1月收治的60例老年脑梗死患者作为研究对象,采用随机数字表法将其分为对照组与观察组,各30例。对照组给予阿替普酶治疗,观察组在对照组基础上给予依达拉奉治疗。比较两组的氧化应激反应指标水平、神经功能缺损评分、日常生活能力评分、临床疗效。结果治疗后,两组的SOD、GSH-Px水平均较治疗前升高,MDA水平均较治疗前降低,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的NIHSS评分均较治疗前降低,Barthel指数评分均较治疗前升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率为93.33%,高于对照组的70.00%,差异具有统计学意义(P<0.05)。结论阿替普酶联合依拉达奉治疗老年脑梗死的效果显著,可改善患者的氧化应激反应及神经功能缺损程度,提高日常生活能力,值得在临床推广和应用。

Objective To analyze the clinical effect of alteplase combined with edaravone in the treatment of elderly cerebral infarction.Methods A total of 60 elderly patients with cerebral infarction admitted from January 2019 to January 2020 were selected as the research objects and divided into control group and observation group by random number table method,with 30 cases in each group.The control group was treated with alteplase,and the observation group was treated with edaravone on the basis of the control group.The oxidative stress response indexes levels,neurological deficit score,activity of daily living score and clinical efficacy of the two groups were compared.Results After treatment,the levels of SOD and GSH-Px in the two groups were higher than those before treatment,and the level of MDA were lower than that before treatment,and those in the observation group were better than the control group,the differences were statistically significant(P<0.05).After treatment,NIHSS score of the two groups were lower than that before treatment,Barthel index score were higher than that before treatment,and those of the observation group were better than the control group,the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 93.33%,which was higher than 70.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion Alteplase combined with edaravone in the treatment of elderly cerebral infarction has a significant effect,it can ameliorate the oxidative stress response and degree of neurological deficit of patients,and improve the activity of daily living,which is worthy of clinical promotion and application.