左乙拉西坦联合奥卡西平治疗儿童局灶性癫痫的临床效果和安全性

Clinical effect and safety of levetiracetam combined with oxcarbazepine in the treatment of focal epilepsy in children

目的探讨左乙拉西坦联合奥卡西平治疗儿童局灶性癫痫的临床效果和安全性。方法选取2018年3月至2020年4月我院收治的90例局灶性癫痫患儿作为研究对象,根据治疗方案将其分为对照组与研究组,各45例。对照组给予奥卡西平治疗,研究组给予左乙拉西坦联合奥卡西平治疗。比较两组的临床效果。结果治疗后,研究组的HMGB1、GFAP、S-100β、NSE水平均低于对照组(P<0.05)。治疗后,研究组的VIQ、PIQ、FIQ评分均高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。研究组的治疗总有效率高于对照组(P<0.05)。结论左乙拉西坦联合奥卡西平治疗儿童局灶性癫痫的效果显著,能有效改善患儿的神经损伤情况,提高认知功能,且未明显增加不良反应,安全性好。

Objective To investigate the clinical effect and safety of levetiracetam combined with oxcarbazepine in the treatment of focal epilepsy in children.Methods A total of 90 children with focal epilepsy admitted in our hospital from March 2018 to April 2020 were selected as the research objects and divided into control group and study group according to the treatment plan,with 45 cases in each group.The control group was treated with oxcarbazepine,and the study group was treated with levetiracetam combined with oxcarbazepine.The clinical effects of the two groups were compared.Results After treatment,HMGB1,GFAP,S-100βand NSE levels in the study group were lower than those in the control group(P<0.05).After treatment,the scores of VIQ,PIQ and FIQ in the study group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion Levetiracetam combined with oxcarbazepine in the treatment of focal epilepsy in children has a significant effect,it can effectively improve the neurological injury of children,improve cognitive function,and does not significant increase the adverse reactions,has good safety.