舒芬太尼和瑞芬太尼麻醉对宫颈癌患者围术期应激反应、免疫功能和细胞因子水平的影响比较

Comparison of effects of sufentanil and remifentanil anesthesia on perioperative stress response,immune function and cytokine levels in patients with cervical cancer

目的比较舒芬太尼和瑞芬太尼麻醉对宫颈癌患者围术期应激反应、免疫功能和细胞因子水平的影响。方法纳入本院2019年3月至2020年2月收治的68例宫颈癌患者,按照随机数字表法将其分为对照组(34例,舒芬太尼麻醉)和观察组(34例,瑞芬太尼麻醉)。比较两组麻醉效果。结果术后,观察组的CRP、ACTH、Cor、IL-6水平均低于对照组,CD4^(+)、CD8^(+)、IL-2、IL-4水平均高于对照组(P<0.05)。观察组术后1、24 h的疼痛、镇静评分及药物追加率均低于对照组,睁眼时间、拔管时间短于对照组(P<0.05)。结论与舒芬太尼相比,瑞芬太尼能够更好地减轻宫颈癌患者围术期应激反应,可充分发挥细胞免疫作用,且麻醉效果、苏醒质量更好。

Objective To compare the effects of sufentanil and remifentanil anesthesia on perioperative stress response,immune function and cytokine levels in patients with cervical cancer.Methods A total of 68 patients with cervical cancer admitted in our hospital from March 2019 to February 2020 were included,and the patients were divided into control group(34 cases,sufentanil anesthesia)and observation group(34 cases,remifentanil anesthesia)according to the random number table method.The anesthetic effects of the two groups were compared.Results After operation,the levels of CRP,ACTH,Cor and IL-6 in the observation group were lower than those in the control group,while the levels of CD4^(+),CD8^(+),IL-2 and IL-4 were higher than those in the control group(P<0.05).The pain,sedation scores at 1 and 24 h after operation and drug addition rate in the observation group were lower than those in the control group,and the eye opening time and extubation time were shorter than those in the control group(P<0.05).Conclusion Compared with sufentanil,remifentanil can better reduce the perioperative stress response of patients with cervical cancer,can give full play to the role of cellular immunity,and has better anesthetic effect and recovery quality.