坤泰胶囊联合氯米芬对多囊卵巢综合征患者子宫内膜容受性及miR-206、IGF-1水平的影响

Effects of Kuntai capsule combined with clomiphene on endometrial receptivity and levels of miR-206 and IGF-1 in patients with polycystic ovary syndrome

目的探讨坤泰胶囊联合氯米芬对多囊卵巢综合征(PCOS)患者子宫内膜容受性及miR-206、胰岛素样生长因子(IGF-1)水平的影响。方法选取2018年9月至2019年10月收治的90例PCOS患者作为研究对象,采用随机数字表法将其分为对照组和观察组,各45例。对照组接受氯米芬治疗,观察组在对照组基础上加用坤泰胶囊。比较两组治疗前、后的子宫内膜容受性、排卵情况及miR-206、IGF-1水平。结果治疗后,观察组的子宫动脉血流阻力指数(RI)、搏动指数(PI)低于对照组,子宫内膜厚度大于对照组(P<0.05)。经期第11 d,观察组的卵泡数目少于对照组,优势卵泡数多于对照组,卵泡成熟时间短于对照组(P<0.05)。治疗后,观察组的miR-206水平明显高于对照组,IGF-1水平明显低于对照组(P<0.05)。结论坤泰胶囊联合氯米芬可提高PCOS患者子宫内膜容受性,改善机体排卵情况,调节miR-206、IGF-1水平,值得临床推广。

Objective To explore the effects of Kuntai capsule combined with clomiphene on endometrial receptivity and levels of miR-206 and insulin-like growth factor 1(IGF-1)in patients with polycystic ovary syndrome(PCOS).Methods A total of 90 patients with PCOS admitted from September 2018 to October 2019 were selected as the research objects,and they were divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with clomiphene,and the observation group was treated with Kuntai capsule on the basis of the control group.The endometrial receptivity,ovulation,miR-206 and IGF-1 levels before and after treatment were compared between the two groups.Results After treatment,the uterine artery blood flow resistance index(RI)and pulsatility index(PI)of the observation group were lower than those of the control group,and the endometrial thickness was thicker than that of the control group(P<0.05).On the 11th day of menstruation,the number of follicles in the observation group was less than that in the control group,the number of dominant follicles was more than that in the control group,and the maturation time of follicles was shorter than that in the control group(P<0.05).After treatment,the miR-206 level of the observation group was significantly higher than that of the control group,and the IGF-1 level was significantly lower than that of the control group(P<0.05).Conclusion Kuntai capsule combined with clomiphene can improve the endometrial receptivity of PCOS patients,and the ovulation of the body,and regulate the levels of miR-206 and IGF-1,which is worthy of clinical promotion.